DNA and Protein Co-Immunization Improves the Magnitude and Longevity of Humoral Immune Responses in Macaques
Figure 5
Env bAb titers in macaques immunized with DNA (D) or DNA together with purified SIV Env (D&P).
(A) Outline of vaccination study. Macaques (N = 4/group) were immunized 4 times (V1 to V4) with SIVmac239 derived vaccines using protocols that included DNA only (D) and DNA&protein (P; SIV gp140 purified from human HEK293 cells) co-immunization. (B) Endpoint bAb titers (log values) to SIVmac239 Env were measured at 2 weeks after each vaccination. Mean and standard deviation (SD) are indicated. P values using repeated measures ANOVA are shown.