Early-Life Exposure to Bisphenol A Induces Liver Injury in Rats Involvement of Mitochondria-Mediated Apoptosis
Figure 4
Perinatal exposure to BPA alters the levels of Cyt c, Bcl-2 and Bax.
(A) Western blot analysis of the Cyt c release from mitochondria into the cytosol in rat livers at 3 and 21 weeks. Western blotting analysis of Bax (B) and Bcl-2 (C) in rat offspring liver at 3, 15 and 21 weeks. The protein expression levels were estimated by densitometry with Gapdh as an internal control. Data are expressed as means ± S.E.M. for three independent experiments (n = 6 rats per group; only 1 offspring was selected per litter).). *P<0.05 compared with controls.