Maintenance of Stemness in Oxaliplatin-Resistant Hepatocellular Carcinoma Is Associated with Increased Autocrine of IGF1
Figure 1
Oxaliplatin treatment in vivo experiments.
(A) Oxaliplatin treatment significantly inhibited the MHCC97H cells s.c. tumor. (B) GS-treated MHCC97H cells s.c. tumors were orthotopically transplanted into livers of other mice, and oxaliplatin treatment of these mice still produced significant therapeutic effects on the tumor tissues. (C) Oxaliplatin-treated MHCC97H cells s.c. tumors were orthotopically transplanted into livers of another mice, and oxaliplatin retreatment of these mice produced no significant therapeutic effects on the tumor tissues. (D) Oxaliplatin-treated MHCC97H cells s.c. tumors were orthotopically transplanted into livers of other mice, and these mice were retreated with oxaliplatin. These mice exhibited increasing pulmonary metastasis compared to the same treatment xenografts from GS-treated MHCC97H cells s.c. tumors (The top are fluorescence microscope photographs of lung tissues, below are Hematoxylin and eosin staining of lung metastasis sections, original magnification×100). Columns, mean of tumor weight of every group; Points, mean of lung metastasis numbers of two groups; bars, SD.