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MRI-Based Computational Model of Heterogeneous Tracer Transport following Local Infusion into a Mouse Hind Limb Tumor

Figure 6

Flow field and tracer distribution following CED of albumin tracer at the center of the tumor for two different flow rates: 1 µL/min and 3 µL/min.

(a & b) Interstitial fluid pressure (IFP) contours for respectively, and (c & d) convective fluid velocity contours at the infusion plane for respectively. Tumor and skin boundaries are overlaid on the contours; the infusion site is designated by a plus sign. (e & f) Predicted 3D tracer distribution volume at the end of infusion (1 hr) shown by an iso-surface of the distribution volume threshold () for respectively. Visible boundaries are for tumor (blue), skin (green) and distribution volume (red).

Figure 6

doi: https://doi.org/10.1371/journal.pone.0089594.g006