Effect of Immunoglobin-Like Transcript 7 Cross-Linking on Plasmacytoid Dendritic Cells Differentiation into Antigen-Presenting Cells
Figure 1
Effect of ILT7 cross-linking on TLR9-induced IFN-α production.
PBMC from healthy donors were cultured overnight with TLR9L in the absence (isotype control) or presence of soluble or plate bound XL-ILT7 (sXL-ILT7 and pbXL-ILT7, respectively). Panel (A) shows box and whiskers plots summarizing IFN-α levels in supernatants from N = 9 independent experiments performed using pbXL-ILT7; horizontal lines within boxes indicate median values, boxes indicate 25th and 75th percentiles, and vertical lines extend to 10th and 90th percentile; numbers above brackets indicate P values for pair wise comparisons (Wilcoxon sign rank test). Panel (B) shows a comparison between sXL-IL7 and pbXL-ILT7 on N = 3 independent experiements; each symbol represents results from one individual donor.