Central Proliferation and Neurogenesis Is Impaired in Type 2 Diabetes and Prediabetes Animal Models
Figure 3
Metabolic parameters are good predictors of cortical and hippocampal atrophy and neurogenesis abnormalities in db/db mice.
Significant negative correlations were detected between metabolic parameters (body weight, glucose and insulin levels) and cortical thickness when all animals under study were analyzed. Data are representative of 30 mice and significant correlations (**p<0.01 and *p<0.05) were detected by Spearman’s rank correlations as follow: A) Body weight/frontal cortex: −0.813**, parietal cortex: −0.696**, hippocampus: −0.539**; B) Glucose levels/frontal cortex: −0.686**; parietal cortex: −0.506**, hippocampus: −0.597*; C) Insulin levels/frontal cortex: −0.657**, parietal cortex: −0.472**, hippocampus: −0.510**; D) BrdU/frontal cortex: 0.40**, parietal cortex: 0.517**.