Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro
Figure 3
Differentially expressed genes in M1 and M2 macrophages vs. monocytes.
Heat-maps representing the fold-expression levels of gene lists identified by SAM as statistically downregulated (green) or upregulated (red) in M1 and M2 samples compared to fresh unstimulated monocytes. The lists excluded genes that are modulated in both M1 and M2 vs. monocytes. (A) Fold-expression levels in monocytes and M1 macrophages of the meta-database for the 98 genes associated to monocyte-to-M1 differentiation. (B) Fold-expression levels in monocytes and M2 macrophages of the meta-database for the 107 genes associated to monocyte-to-M2 differentiation. (C) Fold-expression levels of the 98 monocyte-to-M1 genes assessed in the 60 samples of our in vitro model of inflammation. (D) Fold-expression levels of the 107 monocyte-to-M2 genes assessed in the 60 samples of our in vitro model of inflammation.