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A Modified Approach to Induce Predictable Congestive Heart Failure by Volume Overload in Rats

Figure 4

Electron microscopy in rats 4 weeks after induction of an aortocaval shunt (right) showing a) fragmented nuclear chromatin (#), b) reduced size of myofibrils ( ), c) swollen mitochrondria (←), d) vacuolization (→), e) dissolved cell-cell-contacts with degenerative appearances (*) and f) immigration of phagocytic leukocytes (§).

Magnification: ×10.000.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0087531.g004