Allo-Reactivity of Mesenchymal Stem Cells in Rhesus Macaques Is Dose and Haplotype Dependent and Limits Durable Cell Engraftment In Vivo
Figure 2
Allogeneic MSC administration induces expansion of circulating NK, NKT and B cell subsets in peripheral blood.
(A, B) Representative density plots illustrating the gating strategy used to identify CD3−CD16+, CD3−CD8−CD16+ and CD3−CD16+CD56− NK cell subsets (A) and CD3+CD16+ NKT, CD3−CD16+HLADR+ mDC, CD3−CD8+CD16+HLADR- NK and CD3−CD16−CD20+HLADR+ B cell subsets (B) in peripheral blood by flow cytometry. Plotted values (mean ± SD) represent percentage of different lymphocyte subsets averaged for all transplant recipients within each respective treatment group at the indicated time points. Baseline values were determined as described in figure 1. * P<0.05, **P<0.01. P values were determined using unpaired, two-tailed Student t Test throughout.