Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels
Figure 1
Loss of Ndfip1 results in misregulation of DMT1 and increased susceptibility to iron induced death.
(A) Staining of mouse dopaminergic neurons in culture showed that genetic deletion of Ndfip1 (Ndfip1−/−) resulted in increased DMT1 staining compared to wild type (Ndfip1+/+) dopaminergic neurons. (B) Increasing concentrations of iron resulted in a significant increase in dopaminergic neuronal cell death in Ndfip1 knockout neurons compared to wild type controls. Values are means ±SEM, ** p<0.005, *** p<0.001 un-paired Student t-test. Scale bar: 10 µm.