Mechanisms of Metabonomic for a Gateway Drug: Nicotine Priming Enhances Behavioral Response to Cocaine with Modification in Energy Metabolism and Neurotransmitter Level
Figure 8
Comparison of striatum from mice by applying PLS loading plots for the region 9.4–5.1 and 4.6-0.2 ppm (440 segments) after application of OSC data filter.
(A) control vs. 20 mg/kg cocaine; (B) control vs. nicotine +2 mg/kg cocaine; (C) 2 mg/kg cocaine vs. nicotine +2 mg/kg cocaine; (D) control vs. nicotine; (E) control vs. 2 mg/kg cocaine.