Amantadine Ameliorates Dopamine-Releasing Deficits and Behavioral Deficits in Rats after Fluid Percussion Injury
Figure 6
Investigation of the role of NMDA receptors in the effects of amantadine on dopamine release (A and B) showed the I/O curves of the dopamine released in tonic and bursting release states and (C) showed that the maximum value of dopamine release for tonic and bursting release occurred under 10V stimulation intensity.
The MK 801 may have a particular impct on the amantadine effect in the tonic release state (Fig. 6A and C, 1-P data) without having much effect in the bursting release state (Fig. 6B and C 10-P data). Then MK-801 would shorten the prolonged effect of the amantadine in dopamine reuptake (Fig. 6D). Then amantadine increased the releasing probability of dopamine and the effect would be suppressed by MK-801, while MK-801 alone did not affect the releasing probability (Fig. 6E, comparing the Slope of each group: control vs. MK-801: p = 0.7054, control vs. amantadine: p<0.001***, control vs. amantadine +MK-801: p = 0.0009***, amantadine vs. amantadine+ MK-801: p<0.001 ###). (Note: * indicates p<0.05; ** indicates p<0.01; and *** indicates p<0.001).