Mechanism of Deep-Sea Fish α-Actin Pressure Tolerance Investigated by Molecular Dynamics Simulations
Figure 3
Salt bridge and hydrophobic interactions in actin.
The salt bridges (A) between secondary structures and (B) between subdomains in Yaq at 60 MPa. The residues that form salt bridges with a formation rate of more than 0.5 are shown in Yaq at 60 MPa. Red and blue represent acidic and basic amino acids, respectively. (C) Hydrophobic interactions involving specific substituted residues in Ac1 actin. Red broken lines indicate the hydrophobic interaction. Residues 54 and 67 are different in the actins of deep-sea fish and other species.