GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice
Figure 7
Effect of ethanol on motor activity after pre-habituation.
A. Males (n = 12–20 per genotype; F1,30 = 4.8, p<0.05 main effect of genotype; F2,60 = 13.8, p<0.001 main effect of treatment; no genotype x treatment interaction). B. Females (n = 13–18 per genotype; F2,56 = 18.4, p<0.001 main effect of treatment; no dependence on genotype or genotype x treatment interaction). Values represent mean ± S.E.M. Data were analyzed by two-way ANOVA with repeated measures with Bonferroni post hoc test (#p<0.05 vs. response of another genotype for the same condition). Effect of ethanol within each genotype was also analyzed by one-way ANOVA with repeated measures with Dunnett's post hoc test (*p<0.05, **p<0.01 vs. saline response of corresponding genotype). ρ1 (−/−) = ρ1 null mice; (+/+) = wild type mice; EtOH = ethanol.