GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice
Figure 1
Voluntary ethanol consumption was reduced in ρ1 (−/−) male mice in 24-hour two-bottle choice paradigm.
A. Ethanol consumption (g/kg/24 hours) in males. (F1,18 = 7.1, p<0.05, main effect of genotype; F4,728 = 36.2, main effect of concentration, p<0.001; no genotype x concentration interaction). B. Ethanol consumption (g/kg/24 hours) in females. (F4,68 = 56.2, p<0.001, main effect of concentration; no main effect of genotype or genotype x concentration interaction). C. Preference for ethanol in males. (F1,18 = 7.1, p<0.05, main effect of genotype; F4,72 = 7.8, p<0.001, main effect of concentration; no genotype x concentration interaction). D. Preference for ethanol in females. (F4,68 = 10.6, p<0.001, main effect of concentration; no main effect of genotype or genotype x concentration interaction). E. Total fluid intake (g/kg/24 hours) in males. (F5,90 = 29.9, p<0.001, main effect of concentration; no main effect of genotype or genotype x concentration interaction). F. Total fluid intake (g/kg/24 hours) in females. (F5,75 = 23.8, p<0.001, main effect of concentration; no main effect of genotype or genotype x concentration interaction; n = 9–10 for both genotypes and sexes). Data were analyzed by two-way ANOVA. ρ1 (−/−) = ρ1 null mice; (+/+) = wild type mice; EtOH = ethanol.