Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)2Ru(obip)Ru(dmb)2]4+
Figure 9
Cytotoxic effects of complexes on cells.
MTT assay was performed on human normal fibroblast cells treated with [(dmb)2Ru(obip)Ru(dmb)2]4 A), human cervical cancer Hela cells treated with [(dmb)2Ru(obip)Ru(dmb)2]4+ at gradient concentrations B), Hela cells treated with a clinical chemotherapeutic cisplatin C), K562 cells treated with [(dmb)2Ru(obip)Ru(dmb)2]4 D) and K562 cells treated with cisplatin respectively at gradient concentrations. The inhibition ratio was collected as the average of triplicate wells relative to that of the untreated wells. Result shown here was the representative one among three independent experiments. Data were presented as mean +/- S.E.M.* means P < 0.05, ** means P < 0.005, *** means P < 0.0001 significant difference was observed by GraphPad Prism5 Two-way RM ANOVA (Bonferroni posttests).