Staphylococcus aureus sarA Regulates Inflammation and Colonization during Central Nervous System Biofilm Formation
Figure 5
sarA influences peripheral immune cell influx during CNS catheter-associated infection.
Catheter associated cells were recovered from mice at days 3, 7 and 14-infection, whereupon pooled tissue from 4–5 mice per group (wild type ACH1719– WT vs ACH1719ΔsarA – ΔsarA) was analyzed for neutrophil (A), macrophage (B) and T cell (C) infiltrates, with three independent replicates. Data was corrected for bacterial burdens at each time point. See Figure S2 for representative histograms.