Histopathological Analysis of Salmonella Chronic Carriage in the Mouse Hepatopancreatobiliary System
Figure 6
Chronic hepatitis is exacerbated in infected mice at 3 and 6 months post-infection.
(A) Inflammation grades in the liver at all time points post-infection (± bacteria, ± gallstones). Means of each time point values were compared by a Student’s t test (*, p<0.05; ***, p<0.001). (B) Representative HE images of each group at 3 and 6 months post-infection. Inflammation scores are as follows: B1 (0); B2 (1); B3 and B6 (2); B4 and B5 (4). Infected mice have scattered inflammatory cells distributed randomly within the lobule (B3-B5) and/or in portal areas (B6) composed of neutrophils, lymphocytes, plasma cells and histiocytes. Inflammation was often associated with necrosis of individual hepatocytes (B3) or large confluent areas of hepatocellular necrosis (B4-B5) (noted as N). 20x.