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Low-Anxiety Rat Phenotypes Can Be Further Reduced through Genetic Intervention

Figure 9

Effects of the estrous cycle phases on behaviors in the open field.

Inner (A) and outer (B) locomotion displayed by SLA16 and SHR female rats. Squares and vertical lines represent the means and S.E.M. of animals grouped by estrous cycle phase and strain (n = 4–12/phase/strain). (***) represent significant (p<0.001) overall effect of strain (two-way ANOVA).

Figure 9

doi: https://doi.org/10.1371/journal.pone.0083666.g009