MicroRNA Drop in the Bloodstream and MicroRNA Boost in the Tumour Caused by Treatment with Ribonuclease A Leads to an Attenuation of Tumour Malignancy
Figure 5
qPCR analysis of the expression of miRNA processing genes.
A. Expression of miRNA processing genes in LLC tumour tissue from mice that received RNase A therapy. B. Expression of miRNA processing genes in LLC cells incubated in vitro with intact and DEPC-inactivated RNase A for 48 h. *, **, and *** denote a statistically significant difference relative to the control with p<0.05, p<0.01 and p<0.001, respectively. hprt1 and rpl30 were used as reference genes.