Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier
Figure 2
The kidney phenotype in dendrin knockout mouse.
(a) Dendrin-deficient mice exhibit normal renal morphology by light microscopic examination (hematoxylin-eosin stained section from 2-month old dendrin knockout mouse). Inset: a dendrin-deficient glomerulus with normal morphological features. (b) In electron microscopy podocytes, the glomerular basement membrane and glomerular endothelial cells show normal morphological features. Fine slender podocyte foot processes interconnected by intact slit diaphragms are observed. Bar = 500 nm. (c) 2 ul of urine from 1-year-old wildtype (wt) and knockout (ko) mice was run on SDS-page gel. No albuminuria is detected Ladder showing 50 kD (blue) and 70 kD (orange) bands.