Klotho Suppresses Cardiomyocyte Apoptosis in Mice with Stress-Induced Cardiac Injury via Downregulation of Endoplasmic Reticulum Stress
Figure 11
Klotho regulated the phosphorylation of MAPK.
(A) Representative images of western blotting of p-ERK1/2, ERK1/2, p-p38, p38, p-JNK, JNK and GAPDH in H9c2 cells treated by ISO and/or different concentrations of klotho (0.01, 0.1, 1, 10ug/ml). (B,C,D) Demonstration of the phosphorylation of p-ERK1/2(B), p-p38(C) and p-JNK(D) in ISO, ISO+KL(0.01ug/ml), ISO+KL(0.1ug/ml), ISO+KL(1ug/ml), ISO+KL(10ug/ml) groups. Data are mean±SEM, n=3. * P<0.05 between two compared groups; NS, no significance.