Galectin-3 Silencing Inhibits Epirubicin-Induced ATP Binding Cassette Transporters and Activates the Mitochondrial Apoptosis Pathway via β-Catenin/GSK-3β Modulation in Colorectal Carcinoma
Figure 3
Knockdown of galectin-3 increases the intracellular epirubicin retention.
Cells were pretreated with scrambled shRNA, shGal-3, and/or Epi for 3 h. (A) Three-dimensional view of cell number versus fluorescence intensity in Caco-2 cells. (B) The mean fluorescence intensity of Epi was normalized to 100%. The mean fluorescence intensity of Epi plus shGal-3 was normalized relative to Epi. *, P < 0.05 compared with control and #, P < 0.05 compared with Epi. The data are presented as the means ± SD from three independent experiments.