Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation
Figure 3
Orlistat administration to tumor-bearing mice alters the expression pattern of cell survival regulatory molecules.
Cell lysates of BMC (1x106 cells/ml) harvested from control and orlistat-administered tumor bearing mice were processed for western blot analysis to examine expression pattern of the indicated cell survival regulatory proteins (a,b). Bars shown in (b) are the densitometric scan of bands shown in (a). Data shown is from a representative experiment out of three independent experiments with similar results. Sera harvested from control and orlistat-administered tumor-bearing mice on day 16 post-tumor transplantation were immunodetected by ELISA for the level of the indicated cytokines (c). Values in (c) are mean ± SD of three independent experiments done in triplicate.*p<0.05 vs. values of respective control.