Dynamics and Flexibility of Human Aromatase Probed by FTIR and Time Resolved Fluorescence Spectroscopy
Figure 5
Access channel of rArom for the substrate androstenedione.
A) Overall structure of rArom (PDB ID 4KQ8). The most flexible regions according to the MD simulations [18] are shown in red. The parts of the secondary structure elements forming the access channel are shown in yellow (helix E), cyan (helix F), orange (helix)I, magenta (β-strand 9). B) Zoom in the active site: the heme is shown in red, the Van der Waals surface of androstenedione (blue) and Trp224 (grey) are also shown.