Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo
Figure 7
Working model for the effects of astrocyte secreted MMP-2/-9/-3 on tumor metastasis.
In this model, astrocyte-secreted MMPs and unknown factor(s) induce cleavage of substrates on tumor cell or surrounding cells in the microenvironment that leads to tumor invasion and metastasis. TC: tumor cell; SC: surrounding cell.