5-Aminolevulinic Acid Protects against Cisplatin-Induced Nephrotoxicity without Compromising the Anticancer Efficiency of Cisplatin in Rats In Vitro and In Vivo
Figure 11
Effects of ALA on anti-tumorinogenic effects of cisplatin in vivo.
We evaluated the size of transplantated bladder carcinoma to the F344/NJcl-rnu/rnu rats skin. Rats were divided into four subgroups: 1) a control (saline) group, 2) a cisplatin group, 3) an ALA–treated post cisplatin-injection group, 4) an ALA–treated pre & post cisplatin-injection group (n = 5 for each group), The diameter of the carcinoma were measured at 1, 3. 5, 7, and 9 days after surgery (n = 5/group). Cisplatin reduced size of transplantated renal carcinoma compared with control group. ALA (post and pre & post) did not change the anti cancer effects of cisplatin. Data are the mean ± SEM of 6 experiments per group. *P<0.05 v.s. control by ANOVA.