Effects of N-Acetylcysteine in Ozone-Induced Chronic Obstructive Pulmonary Disease Model
Figure 7
Immunohistochemical analysis of the expression of apoptosis protease activating factor-1 (APA-1) in airway epithelium and parenchyma of air-exposed mice (Panel A, G ), PBS-pretreated ozone-exposed mice (Panel B,H ), NAC-pretreated ozone-exposed mice (Panel C, I ), air-exposed mice (Panel D, J), ozone-exposed PBS-treated mice (Panel E, K) ozone-exposed NAC-treated mice (Panel F, L). Scale bar: 10µm for airway epithelial pictures and 20μm for lung parenchymal pictures. Panel M. Individual and mean immunostaining scores of staining for APA in airway epithelial cells from the 6 experimental groups. Panel N. Individual and mean score values of APA-1 positive cells counted in the lung parenchyma. *P<0.05, **P<0.01, *** P<0.001.