Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease
Figure 3
GTPase inhibition prevents 5/6Nx-induced renal fibrosis.
RT-PCR analysis of renal TGFβ, fibronectin and smooth muscle α-actin (α -SMA) expression (A), and expression of podocyte specific markers podocin, nephrin and WT-1 (B) detected in renal cortex homogenates. Polymerase 2a (Polr2a) served as housekeeping gene. Data are expressed as mean ± SEM from four mice of each group. *P<0.05 vs. corresponding sham control; # P<0.05 vs. 5/6Nx control.