Exercise Promotes Axon Regeneration of Newborn Striatonigral and Corticonigral Projection Neurons in Rats after Ischemic Stroke
Figure 4
Increase of the formation of newborn projection neurons in adult ischemic brain by exercise post-stroke.
Double immunohistochemical staining of FG (blue) and GFP (brown) was used to detect newly generated projection neurons. A: Histochemical photographs showed GFP+-FG+ double staining cells as indicated by double red arrowheads. GFP+ and FG+ single-labeling cells were indicated by single red arrow and arrowhead, respectively. B: Quantitative analysis showed that exercise post-stroke significantly increased the number of newborn striato- and cortico-nigral projection neurons in ischemic rat brain. Data are shown as mean ± S.E.M. MCAO group (n = 8); MCAO+Ex group (n = 6). *P<0.05 vs MCAO group. Scale bar in A is 100 µm.