The Development of a Preference for Cocaine over Food Identifies Individual Rats with Addiction-Like Behaviors
Figure 4
Cocaine preferring rats have increased motivation for cocaine and reduced motivation for pellets.
Motivation to self-administer cocaine and pellets in pellet preferring (PP) and cocaine preferring (CP) rats (white and black bars, respectively). Differences between males (M) and females (F) were not examined. Significant difference between PP and CP rats (# p<0.05). Significant difference between early and late in self-administration (* p<0.05). Significant difference between pellet nose pokes (NP) and cocaine nose pokes (NP) within a given group and time (∧ p<0.05). PP females (n = 6), PP males (n = 10), CP females (n = 6) and CP males (n = 2). Vertical lines represent +SEM.