Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
Figure 6
Long run stochastic trajectories in the absence of external stimulation.
(A, B) WT cells for = 0.05 and = 0.025, respectively, and TNFR1 receptors number = 7000. (C, D) Zoomed fragments of trajectory showing (C) small stochastic fluctuations in the vicinity of the stable steady state and (D) large amplitude oscillations in the basin of attraction of the stable limit cycle. (E) Fraction of oscillating WT and A20 cells as a function of . (F, G) A20 cells trajectories for = 0.006 and = 0.004.