Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
Figure 5
Stochastic versus deterministic solutions for WT cells.
(A) ; thick red line and red dot – stable limit cycle and stable steady state for the deterministic approximation; blue line – example stochastic trajectory (total simulation time: 70 h). (B) ; red line – deterministic damped oscillations in response to 5-min pulsed 1 ng/ml TNFα; blue line – example stochastic trajectory (total simulation time: 70 h) in the absence of TNFα stimulation.