A ΔclpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia
Figure 2
In vivo growth kinetics of FSC200 ΔclpB vs LVS following ID vaccination.
BALB/c mice (n = 4/group) were immunized ID with ∼105 CFU of FSC200 ΔclpB (circle) or LVS (square). Mice were killed on days 2,4,7,and 14 for bacteriology. *, significantly higher burden vs LVS. Symbols not shown for organ burdens below detectable limits (100 CFU).