Helicobacter pylori Cholesteryl α-Glucosides Contribute to Its Pathogenicity and Immune Response by Natural Killer T Cells
Figure 2
Ribbon model of αCgT adapted from crystal structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis.
Homology modeling of αCgT was performed by alignment of αCgT in H. pylori 26695 (wild type) and PimA in M. smegmatis. Amino acid substitutions observed in Japanese clinical isolates that increase (yellow) and decrease (blue) enzyme activity relative to WT αCgT are shown. The figures are adapted from a figure previously reported in [35].