Changes in Sensitivity of Reward and Motor Behavior to Dopaminergic, Glutamatergic, and Cholinergic Drugs in a Mouse Model of Fragile X Syndrome
Figure 6
Anatomical and biochemical correlates of dopaminergic function in wild type (WT, white bars) and Fmr1-/Y mice (red bars).
A. Mean numbers of tyrosine hydroxylase (TH) expressing neurons (± SEM, top) in the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) of WT and Fmr1-/Y mice estimated with design-based stereology. Numbers of mice are indicated in each column. Ventral midbrain image (bottom left) is magnified 4x and inset showing TH staining (bottom right) 40x. Asterisks (*) indicate p < 0.05 vs. WT. cp = cerebral peduncle; fr = fasciculus retroflexus; ml = medial lemniscus. B. Mean ratio of TH to β-Actin staining intensity expressed as percentage of mean WT values (± SEM, top) in western blots of homogenates from dorsal striatum and nucleus accumbens (NAc) of WT and Fmr1-/Y mice. Numbers of mice are indicated in each column. Representative bands (bottom) are shown for each column above.