Urotensin II Inhibits Skeletal Muscle Glucose Transport Signaling Pathways via the NADPH Oxidase Pathway
Figure 2
Effect of urantide on MDA content and GSH-Px activity in soleus muscle in mice.
KK mice were administrated urantide (30 µg/kg/day) for 14 days prior to measurement of (A) MDA content by thiobarbituric acid assay and (B) GSH-Px activity using a Glutathione Assay Kit. Control (C57BL mice were treated with saline for 14 days), Urantide (C57BL mice were treated with urantide for 14 days), KK (KK mice were treated with saline for 14 days), KK+Urantide (KK mice were treated with urantide for 14 days). Control: C57BL/6J mice were treated with saline for 14 days; Urantide: C57BL/6J mice were treated with urantide for 14 days; KK:KK mice were treated with saline for 14 days; KK+Urantide: KK mice were treated with urantide for 14 days. Data are presented as the relative increase compared with control (100%; n=6-8, *P<0.05 vs control; # P<0.05 vs KK group).