Synergistic Analgesia of Duloxetine and Celecoxib in the Mouse Formalin Test: A Combination Analysis
Figure 3
Celecoxib dose-dependently inhibited formalin induced spontaneous flinching of the injected hind paw.
Spontaneous flinchings during 60 min after s.c. formalin injection from different groups were shown in A. The AUCs for different groups were calculated to perform statistical analysis on the first (B) and second (B’) phases. The dose-effect or log (dose)-effect curves for celecoxib’s analgesic effects were shown in C and D (first phase) or C’ and D’ (second phase).