Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells
Figure 5
Urea cycle and the metabolism of arginine and proline.
(A) Upregulated enzymes in green, downregulated enzymes in red. Upregulated metabolites in dark red, downregulated metabolites in blue. (B) Cell viability after knockdown of GFP (negative control), PRODH, PYCR2 or PARS2 in presence or absence of 5 µM cisplatin.