Interleukin 15 Primes Natural Killer Cells to Kill via NKG2D and cPLA2 and This Pathway Is Active in Psoriatic Arthritis
Figure 4
PsA patients have higher levels of IL-15 in their synovial tissue, providing an environment wherein NK cells are primed to the effector stage.
(A) IL-15 is upregulated in the synovial tissue of patients with PsA but not AS, as shown by immunohistochemical staining using an anti-IL-15 mAb. Staining of a PsA tissue preparation with an isotype control antibody is shown on the left. Images are representative of at least three independent experiments. (B) Stress ligand levels are higher in the synovial tissue of PsA patients compared to patients with AS, as shown by immunohistochemical staining using an anti-MIC mAb. An isotype control is shown on the left as in (A). Images are representative of at least three independent experiments.