Dosage Considerations for Transcranial Direct Current Stimulation in Children: A Computational Modeling Study
Figure 9
Approaches to normalize dose across populations.
Top- Even in cases when individual modeling is practical for every subject in a study, criterion (based on population response) may be rewired to selected desired brain electric field parameters. Bottom: For each given montage and age range, there is a distribution of sensitivity (defines as the electric field in the brain per mA of current applied). In cases where the peak electric field is outside the nominal target (as is typical the case for sponge montages) further consideration should include both brain wide peak electric field and local electrical field maxima inside the nominal target. In the case of 4x1 HD-tDCS, the peak electric field is inside the ring so at the nominal target. When determining a normalized dose for a pediatric population is thus important to recognize scaling will be both montage and age dependent.