A Novel Branched Chain Amino Acids Responsive Transcriptional Regulator, BCARR, Negatively Acts on the Proteolytic System in Lactobacillus helveticus
Figure 9
Model for the regulation of the proteolytic system of L. helveticus by the BCARR protein.
Release of the long peptide containing VPP and IPP sequences by an extracellular proteinase (I), uptake of the long peptide via oligopeptide transporter (II), intracellular processing of the peptides to amino acids by peptidases (III), BCARR (ACT domain)-BCAA complex formation (IV), binding of the complex (CBS domain) to the BCARR-box and repression of proteolysis gene transcription (V) and repressed release of the antihypertensive peptides, VPP and IPP (VI). L; Leucine, I; Isoleucine, V; Valine. T arrows indicate repressive effects.