Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice
Figure 3
Morris water maze performance of 11-month-old AβPP-PS1 and wild-type mice on control and multi-nutrient diets.
Spatial learning was measured in a 4-day acquisition phase, by determining the latency to find a hidden platform in the NE quadrant. Spatial memory was tested in the probe phase in which the percentage of time spent in the target NE quadrant, the time spent in the former platform area, the latency to the former platform area and the total distance moved were measured. A: Both AβPP-PS1 and wild-type mice showed a decrease in latency during training. Overall escape latencies were higher in AβPP-PS1 mice (*p<0.001), independent of dietary intake. B: Animals on control (CO), the DHA, EPA and UMP (DEU) and Fortasyn® Connect (FC) diets showed a similar decrease in latency during training, independent of genotype. Overall escape latencies were not affected by dietary intake. C: AβPP-PS1 mice spent less time in the target NE quadrant than wild-type mice, independent of dietary intake (*p = 0.033). Time spent in the NE quadrant was unaffected by dietary intake. D: AβPP-PS1 mice spent less time in the former platform area than wild-type mice (*p = 0.010), independent of dietary intake. Time spent in the exact former platform area was unaffected by dietary intake. E: AβPP-PS1 mice had a higher latency to reach the former platform location than wild-type mice (*p = 0.003), independent of dietary intake. Latency to reach the former platform location was unaffected by dietary intake. F: AβPP-PS1 mice on FC diet displayed a shorter swim distance compared to wild-type mice on FC diet (*p = 0.009) and compared to AβPP-PS1 mice on CO diet (*p = 0.013), but not compared to AβPP-PS1 mice on DEU diet.