Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice
Figure 1
Time line of experimental design.
At 2 months of age, AβPP-PS1 mice and their wild-type littermates were put on either a control diet (CO), a DHA, EPA and UMP diet (DEU) or a Fortasyn® Connect diet (FC) for the remainder of the experiment. Behavioral testing was performed at 11 months of age. Animals were weight one week before starting the behavioral testing battery. In the first week of behavioral testing, animals were exposed to the open field once for 30 minutes. In the second week, animals were trained in the Morris water maze (MWM) for 4 days. In the third week, animals were trained in the reverse Morris water maze (rMWM) for 2 days. MR imaging was performed at 12 months of age. Mice were weighed before MR scanning and sacrificed immediately after MR imaging.