Biodistribution and Subcellular Localization of an Unnatural Boron-Containing Amino Acid (Cis-ABCPC) by Imaging Secondary Ion Mass Spectrometry for Neutron Capture Therapy of Melanomas and Gliomas
Figure 2
SIMS imaging analysis of 39K and 11B distributions in B16 melanoma.
The B16 melanoma bearing mouse was euthanized 1 hr after i.p. administration of cis-ABCPC. The photomicrograph is an H&E stained 4µ cryosection of the B16 melanoma. SIMS images were recorded from the adjacent 4µm thick cryosections. The SIMS 39K+ image was integrated on the CCD camera for 0.2 sec and 11B+ image for 2 min.