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Regulatory Scientific Advice on Non-Inferiority Drug Trials

Figure 1

Search strategy and result.

Note: 1. Final scientific advice letters were excluded if they were not related to non-inferiority trials; 2. In the analysis, 156 final scientific advice letters were included, containing 278 different questions (including their company position and CHMP response); 3. Each company question, company position and CHMP response may contain more than one topic.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0074818.g001