GSTCD and INTS12 Regulation and Expression in the Human Lung
Figure 1
Genetic architecture of the region containing both GSTCD and INTS12 genes.
The top panel depicts gene arrangements previously reported in NCBI, build 37, whereas the lower panel shows novel variants identified in lung. V1, 2, 3 refer to splice variants 1, 2 and 3 for each gene. Open boxes represent exons and connecting black lines represent introns. Also illustrated are the locations of Single Nucleotide Polymorphisms (SNPs) meeting genome-wide association (P≤5x10-8) for FEV1 in previously reported analyses of the SpiroMeta consortium [5]. Highlighted in red is the sentinel SNP rs10516526 that was associated with FEV1 (P=2.18 x 10-23 in all stage analyses) [5]. Translation start codons (ATG) are shown boxed in green and stop codons (TAA) boxed in red.