AutomiG, a Biosensor to Detect Alterations in miRNA Biogenesis and in Small RNA Silencing Guided by Perfect Target Complementarity
Figure 3
Screening of chemical compounds using the automiG construct.
Fluorescence fold-change (A) and fluorescent spot count (B) distributions in negative controls with DMSO only. Fluorescence fold-change (C) and fluorescent spot count (D) distributions in wells with compounds from the chemical libraries. Note the logarithmic scales for these distributions. Red lines correspond to the cut-offs used for selection of the compounds.