Distal Effect of Amino Acid Substitutions in CYP2C9 Polymorphic Variants Causes Differences in Interatomic Interactions against (S)-Warfarin
Figure 5
Network of hydrogen bonds formed by R144 in WT.
(a) On the surface of the WT structure, helices C, D, and H are held by the network of hydrogen bonds indicated by black lines. The bonds are formed by guanidino group of R144 and carbonyl oxygen on the backbone of M136, R139, S140, and Q261. Such interactions are absent in R144C structure (b) due to a replacement of arginine to cysteine.