Distal Effect of Amino Acid Substitutions in CYP2C9 Polymorphic Variants Causes Differences in Interatomic Interactions against (S)-Warfarin
Figure 2
Porcupine plot of the first eigenvector obtained from PCA.
Dominant motions of residues in WT (a), R144C (b), I359L (c) and L90P (d) are indicated by arrows on ribbon representation of each variant in different colorings. Magnitude of motions is illustrated by length of arrows.